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李惠静

作者:院办  添加时间:11-09-16 点击:6834

一、基本信息

       名: 李惠静

职务职称: 博士/教授/博士生导师

       别: 

专    业: 精细化学品合成/天然产物化学

电子邮箱: lihuijing@iccas.ac.cn

个人主页: http://homepage.hit.edu.cn/pages/lihuijing

 

二、目前主要研究方向

1. 精细化学品合成

2. 绿色制备新方法与新技术

3. 海洋天然产物分离分析、结构鉴定、合成、结构修饰以及构效关系研究

三、学习经历

2004  中国科学院化学研究所   有机化学   博士学位

四、工作经历

2004 美国奥勒冈州立大学,天然产物化学,博士后

2009 法国巴黎大学,金属有机化学,博士后

2011 哈尔滨工业大学(威海)海洋科学与技术学院,副教授

2014  哈尔滨工业大学(威海),教授,博士生导师  

五、主要研究成果与获奖情况

11997 中国化学工业部科技兴化奖

2. 国家自然科学基金(青年)具有重要生物活性的啤酒花多酚类天然产物的全合成和结构修饰研究 负责人

3. 国家自然科学基金(面上)镓催化的环异构化反应研究及其在几种天然产物合成中的应用 负责人

4. 北京分子科学国家实验室开放基金啤酒花A型原花色素类化合物的合成研究 负责人

5. 山东省科技攻关— 活性构象导向的海洋天然抗癌药物的研制 负责人

6. 中国科学院分子识别与功能重点实验室开放基金—A型原花色素类天然产物全合成研究 负责人

7. 威海市科技攻关重点项目海洋船舶防污导向的天然产物全合成与结构修饰负责人  

六、主要学术兼职

1.中国化学会会员

2.法国化学会会员

3.美国质协会会员

七、发表论文选列

在国内外期刊上公开发表SCI文章近40篇,书籍2部(第1作者),应邀口头报告4次(第1作, 者),会议论文6篇(第1作者4篇)。代表性论文著作:

[1] Wu Qin-Xi, Li Hui-Jing,* Wang Hong-Shuang, Zhang Zhen-Guo, Wang Chen-Chao and Wu Yan-Chao. "Catalyst-free synthesis of spiropyrazolines from chalcones and cyclic-ketone N-tosylhydrazones." Synlett 2015, DOI: 10.1055/s-0034-1379616 (online).

[2] Li Hui-Jing,* Wu Ying-Ying, Wu Qin-Xi, Wang Rui, Dai Chun-Yang, Shen Zhi-Lun, Xie Cheng-Long and Wu Yan-Chao. "Water-promoted ortho-selective monohydroxymethylation of phenols in NaBO2 system." Org. Biomol. Chem. 2014, 12 (19), 3100–3107.

[3] Li Hui-Jing,* Deng Kai, Luo Dong-Hui, Liu De-Hui, Wang Jun-Li, Lin Chun-Hua and Wu Yan-Chao. "Synthesis of functional 4H-chromenes from phenols and acetophenones under solvent- and metal-free conditions." RSC Adv. 2014, 4 (50), 26316–26324.

[4] Li Hui-Jing, Wu, Yan-Chao,* Dai Jian-Hong, Song Yan,* Cheng Runjiao and Qiao Yuanyuan. "An "ortho effect" in electrophilic aromatic nitrations: Theoretical analysis and experimental validation." J. Chin. Chem. Soc. 2014, 61(12), 1307–1312.

[5] Li Hui-Jing,* Luo Dong-Hui, Wu Qin-Xi, Dai Chun-Yang, Shen Zhi-Lun and Wu Yan-Chao. "Bi(OTf)3-catalyzed tandem reaction of naphthols with β,γ-unsaturated α-ketoesters. Efficient synthesis of functionalized 4H-chromenes." Chin. Chem. Lett. 2014, 25 (9), 1235–1239.

[6] Li Hui-Jing, Song Zhi-Fang, Yu Junqiang, Li Yang, Feng Ling and Huai Qi-Yong. "Synthesis and performance of ferrocene-bonded chiral stationary phase for RP-HPLC." Asian J. Chem. 2014, 26 (14), 4465–4468.

[7] Li Hui-Jing, Wu Yan-Chao,* Dai Jian-Hong, Song Yan,* Cheng Runjiao and Qiao Yuanyuan. "Regioselective electrophilic aromatic bromination: theoretical analysis and experimental verification." Molecules 2014, 19 (3), 3401–3416.

[8] Li Hui-Jing,* Wang Jun-Li, Wang Rui, Luo Dong-Hui and Wu Yan-Chao. "Synthetic studies on potent marine drugssynthesis and the crystal structure of 6-tert- butyl-4-phenyl-4H-chromene-2-carboxylic acid." J. Chem. 2013, Article ID 106908.

[9] Li Hui-Jing, Deinzer Max L. “Chapter 32-Proanthocyanidins in hops” in Beer in Health and Disease Prevention (Editor(s): Preedy, Victor R. Publisher: Elsevier Inc., Burlington, England), 2009, 333–348.

[10] Li Hui-Jing, Deinzer Max L. “Chapter 9-Polyphenolic Compounds in Hops” in Hop Flavor and Aroma (Editor(s): Thomas H. Shellhammer. Publisher: Master Brewers Association of the Americas, Minnesota, USA), 2009, 99–121.

[11] Li Hui-Jing, Deinzer Max L.* “The mass spectral analysis of isolated hops A-type proanthocyanidins by electrospray ionization tandem mass spectrometry” J. Mass Spectrom. 2008, 43(10), 1353–1363.

[12] Li Hui-Jing, Deinzer Max L.* “Tandem mass spectrometry for sequencing proanthocyanidins” Anal. Chem. 2007, 79, 1739–1748.

[13] Li Hui-Jing, Deinzer Max L.* “Structural identification and distribution of proanthocyanidins in 13 different hops” J. Agr. Food Chem. 2006, 54, 4048–4056.

[14] Li Hui-Jing, Tian Hong-Yu, Wu Yan-Chao, Chen Yong-Jun, Liu Li, Wang Dong,* Li Chao-Jun.* “Aqueous asymmetric Mukaiyama aldol reaction catalyzed by chiral gallium Lewis acid with Trost-type semi-crown ligands” Adv. Synth. Catal. 2005, 347, 1247–1256.

[15] Li Hui-Jing, Zhao Jun-Ling, Chen Yong-Jun, Liu Li, Wang Dong,* Li Chao-Jun.* “Water-promoted direct aerobic oxidation of enol silyl ether to alpha-hydroxyl ketones without catalyst” Green Chem. 2005, 7, 61–63.

[16] Li Hui-Jing, Tian Hong-Yu, Chen Yong-Jun, Wang Dong,* Li Chao-Jun.* “Chiral anionic surfactants for asymmetric Mukaiyama aldol-type reaction in water” J. Chem. Res. 2003, 153–156.

[17] Li Hui-Jing, Tian Hong-Yu, Chen Yong-Jun, Wang Dong,* Li Chao-Jun.* “Novel chiral gallium Lewis acid catalysts with semi-crown ligands for aqueous asymmetric Mukaiyama aldol reactions” Chem. Commun. 2002, 2994–2995.  

 

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